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Trivia: The first credited acting role for Hayden Panettiere in five years. Panettiere had taken a four-year hiatus from acting starting in 2018 to work on her physical and mental health after a series of personal issues. When she found out the "Scream" franchise was being brought back in 2022, she called the directors and pitched the idea that her character Kirby could return in a future installment. While her cameo in that film was cut, the directors promised she'd be back for the sixth film.

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Continuity mistake: When Specs starts the process of trying to hypnotize Imogen, after he makes his "E.T." jokes, as it cuts back and forth between him and Imogen, his hand is either raised or lowered instantly depending on the angle.

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Continuity mistake: When Elise finds the skull in the suitcase, she's holding it above the center of the case. When it cuts to the opposite angle, suddenly she's holding it over the side of the case.

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Continuity mistake: When Tucker prices the fan out of the wall, he places his flashlight down inside of the vent, and it's pointed slightly to the right side of screen. When we see the suitcase hidden in the vent few shots later, we can see the flashlight's beam hitting it right around the center... which is impossible from the direction the flashlight was facing in the opposite camera angle.

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Visible crew/equipment: When Elise has a vision of Gerald holding a girl captive in the basement, after he makes her drink the fluid to make her sleep, he turns and walks out of the room. As he does so, you can briefly see the tip of a boom mic dip into frame twice from above camera.

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Continuity mistake: When Elise walks over to the grated fan and finds something inside, the way she's holding the front of the fan changes instantly between cuts. (Her hand lowers a good 8 inches between cuts).

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Audio problem: When Elise sends Specs and Imogen to get the bible from upstairs, Tucker protests, saying "he gets bible camp with the most beautiful girl on earth...", but his mouth movements don't quite match the words "he gets bible camp", revealing the line was re-recorded in post. (The rest of the line matches, but not those four words).

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Continuity mistake: When Elise leaves the interview with the detective at the hospital, his hand goes from up and holding a pen to down flat on the table holding nothing instantly between cuts.

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Continuity mistake: When Elise is being interviewed in the hospital by the detective, the way he's holding his pen instantly changes between shots as we cut from outside to inside the room.

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Continuity mistake: After Specs kills Ted, we see Elise being interviewed by police outside as Mara is taken away to the hospital. Depending on the camera angle, sometimes Elise has police lights reflecting on her face, and sometimes not. It changes instantly between cuts several times. There are a few other minor continuity gaffs with the police lights throughout the scene as well.

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Continuity mistake: When Specs kills Ted by pushing the armoire onto his head, when it crashes down, a huge crack forms in the side of it. The crack is missing in every subsequent shot of the armoire.

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Visible crew/equipment: When Elise and Tucker open the hidden door, in the closeup of Elise, you can faintly see set-lights reflecting in her and Tucker's eyes. The the room in front of them is totally pitch-black, so there's no other light source that could be creating these light reflections.

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Continuity mistake: When Tucker takes the hidden door from Elise and finishes opening it, he goes from holding it with one hand to both hands instantly between cuts.

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Continuity mistake: When Elise uses the key to open the hidden door in the basement, her left hand suddenly appears on the door instantly between cuts. (It wasn't there in the previous shot).

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Continuity mistake: After Elise returns to the basement with the keys, Tucker is holding his flashlight above his shoulder. It then cuts to a closeup of him, and he raises his flashlight above his shoulder a second time.

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Revealing mistake: Normally I wouldn't consider a bad CGI effect to be a mistake, but when Elise finds the hidden keyhole in the wall in the basement, the effect is comical if you pay attention. The way it appears as she scratches is pretty unnatural, and the pieces of paint that fall practically look like cartoon pieces if you pay attention. The shadow of her left hand also looks a little too sharp compared to the rest of her (somewhat softer) shadow, revealing it was likely rotoscopped in some way.

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Continuity mistake: When Elise is communicating through the wall by asking yes-or-no questions and getting responses via whistle, in the shots facing Elise, she's staring forward directly forward. But in the shots facing the wall, her head is turned sideways and pressed up against the wall. This happens instantly between cuts at least once.

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Continuity mistake: When Elise and Tucker go down into the basement and hear the whistle, Elise approaches the wall. As she does, her right arm is bent up by her abdomen. When the camera cuts, you can see from her shadow that her right arm is instantly now down by her side.

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Continuity mistake: When Elise and Tucker go down into the basement, they hear the whistle and Elise spins around in shock. Between cuts, she instantly goes from holding her flashlight above her shoulder, to holding it down by her chest.

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Continuity mistake: During the second night of the investigation, after Tucker and Elise hear the whistle, Tucker opens the door. The shadow his hand and microphone are casting on the door changes positions between edits when it cuts to the POV of him grabbing the doorknob. (First it's on the door, then off).

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