Dolores: Well, you wanna tell me what she was doing with her arms around you?
Eddie Valiant: Probably looking for a good place to stick a knife.
Dolores: Oh come on, Eddie, I caught you with your PANTS DOWN!
R.K. Maroon: You've got it all wrong! I'm a cartoon maker, not a murderer!
Eddie Valiant: Everybody's gotta have a hobby!
Eddie Valiant: Here's to the pencil pushers. May they all get lead poisoning.
Jessica Rabbit: You don't know how hard it is being a woman looking the way I do.
Eddie Valiant: You don't know how hard it is being a man looking at a woman looking the way you do.
Jessica Rabbit: I'm not bad. I'm just drawn that way.
Eddie Valiant: Anybody know you're here?
Roger Rabbit: Nobody. Not a soul, except, uh...
Eddie Valiant: Who?
Roger Rabbit: Well, you see, I didn't know where your office was. So I asked the newsboy. He didn't know. So I asked the fireman, the green grocerer, the butcher, the baker, they didn't know! But the liquor store guy... He knew.
Eddie Valiant: In other words, the whole town knows you're here! Get out!
Roger Rabbit: Yeah. Check the probate. Why, my Uncle Thumper had a problem with HIS probate, and he had to take these big pills, and drink lots of water.
Eddie Valiant: Not prostate, you idiot, PROBATE!
Answer: There's really a lot of possible reasons he hates other toons. There's a whole Roger Rabbit book and comic book series that explain Doom's background more. In the film, he's greedy and wants to destroy Toon Town to build the freeway to make more money. In human disguise he's also seen as merciless and is just punishing toons to maintain law and order, etc. Although that's just an excuse to kill toons as well. However, not explained in the film; as a toon he was cast as the antagonist in cartoon films until an accident one day left him thinking he was an actual villain (as opposed to just an actor playing one). That's when he began his life of crime, including killing Teddy Valiant. So his hatred of toons is more about him being evil and not a personal vendetta against them, like Blade's motives.