Mission: Impossible 2

A scientist named Dr. Nekhorvich (Serbedzija), who is a friend of IMF agent Ethan Hunt (Cruise), who is in Australia, wants him to escort him to Atlanta, which he does. While on the plane something bizarre happens and Ethan kills the scientist. It is then revealed that Ethan is not Ethan but Sean Ambrose (Scott) posing as him. He and his cohorts jump out of the plane and then proceed to crash it into a mountain. The real Ethan is then summoned by his superior for a mission but before undertaking it he is instructed to recruit a woman named Nyah Hall (Newton), who is a thief to help them. He does and goes to meet his boss who tells him about his friend and the crash. He then tells him since Ethan was unavailable he sent another agent Sean Ambrose who like Ethan is a disguise expert. They then conclude that Ambrose was the one who crashed the plane and took what his friend was carrying, which he called Chimera. Ethan's mission is to get it back. He is then told that Nyah is Sean's old girlfriend and that he wants her back. Ethan is hesitant because it seems that the two of them have connected but is convinced that she is their best chance to find Ambrose, so he asks her and she agrees.

Factual error: In the scene at the race track where they show the virus infecting and destroying cells in the blood stream, they clearly show that it is red blood cells being infected. Viruses, in order to replicate, require the cell's DNA replication machinery. However, mature red blood cells in the circulation no longer possess this machinery since they no longer have a nucleus or DNA. It would therefore be impossible for this virus to replicate.

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Sean Ambrose: In just a few hours you can be assured of going down in history as the typhoid Mary of "Aus." G'day.

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Trivia: When Nyah is trying to convince Ethan to shoot her, she says "Do it. Now!" There is still about forty minutes left in the movie, but those are the last words she says.

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Question: When Ambrose noticed the envelope was in the wrong pocket, and was thus tipped off that Nyah was a spy, how did he jump to the conclusion that Ethan was her contact? Did he play a mere hunch when he impersonated Ethan in front of her?

Answer: Ethan was the most probable candidate. Remember that Ambrose and Ethan had specifically worked together a few times with IMF in the past, as stated in the film, with them body doubling each other. Once Ambrose had his suspicious raised by the envelope, he decided to test Nyah. So showing up to her with Ethan's face would indicate if she recognized Ethan, or thought she was being approached by a total stranger at night.

Quantom X

Answer: Ambrose has stolen Chimera, a virus developed by Dr. Nekhorvich. Dr. Nekhorvich was an associate of Hunt, and trusted him. This is why Ambrose had to pose as Hunt to extract him at the beginning. Given that Ambrose was posing as hunt on the mission he went rogue, it is logical that Hunt would be the one sent to take him down.

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