Trivia: In the widely released version of Osmosis Jones in the background of the opening chase scene, a remix of Foreigner's 'Hot Blooded' plays, but in the VHS release it plays Electric Avenue by Eddy Grant.
Trivia: Thrax is like Morpheous from the Matrix trilogy. His black coat, black glasses and he is even voiced by Laurence Fishburne. In his end fight with Osmosis there is a very clear Matrix reference (the bullettime effect).
Trivia: In the line to the bladder, when Jones is trying to stop Drix from leaving, you see one of the creatures holding Pikachu from Pokémon (when Jones says "get your time-release butt off this boat"). At the time of the film, 2001, the Pokémon TV series was airing on Kids' WB and WB was the distributor of "Osmosis Jones."
Trivia: Originally there was going to be a toy line made for Osmosis Jones, but WB lost faith in the project and canceled their release. Only prototypes of the toys exist today.
Answer: Just like Frank, Shane's mom never ate healthily. Instead, like Frank, she probably just ate whatever she wanted, so she most likely died from a heart attack from eating unhealthy foods or from obesity.