Plot hole: In the waning seconds of the championship game, the Huskies are down by 2 and UMass has the ball. Not only do the Huskies not intentionally foul to stop the clock, but UMass attempts to run a play and set up a basket when they simply could have dribbled out the clock and won the game. Both these strategies go against what any basketball team would do in this situation, especially in a championship game.
Other mistake: When Mimi wants to dance, and she wipes the diner table clean, the table is about 2 feet square. When Mimi and Jimmy dance, they are 6 feet apart, despite dancing on that small table. (00:39:00 - 00:39:40)
Continuity mistake: Dr. Werner Ernst is talking with nurse Stella as he has his cup of hot liquid. She asks him "Is the world really that shallow?" James Spader is holding the cup from the top without using the handle, but in the next shot he is holding it from the side instead as he puts it down on the desk. (00:04:35)
Continuity mistake: In the sequence with Terence Hill and Marvin Hagler giving chase to the bad guys, when the baddies break the guard-rail and supposedly drop one level, the lights of the chasing car are still fully visible through the back window before the good guys take the same dive from the highway ramp.